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'Mix and match' UK Covid vaccine trial expanded


‘Mix and match’ UK Covid vaccine trial expanded – BBC News

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“,”blocks”:[“type”:”fragment”,”model”:”text”:”A major UK trial looking at whether Covid vaccines can be mixed with different types of jabs used for first and second doses is being expanded. “,”attributes”:[“bold”,”bold”]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Combining vaccines might give broader, longer-lasting immunity against the virus and new variants of it, and offer more flexibility to vaccine rollout. “,”blocks”:[“type”:”fragment”,”model”:”text”:”Combining vaccines might give broader, longer-lasting immunity against the virus and new variants of it, and offer more flexibility to vaccine rollout. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[{“type”:”paragraph”,”model”:{“text”:”Adults over 50 who have had a first dose of Pfizer or AstraZeneca can apply to take part in the Com-Cov study. “,”blocks”:[“type”:”fragment”,”model”:”text”:”Adults over 50 who have had a first dose of Pfizer or AstraZeneca can apply to take part in the “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”Com-Cov”,”locator”:”https://comcovstudy.org.uk/home”,”blocks”:[“type”:”fragment”,”model”:”text”:”Com-Cov”,”attributes”:[]],”type”:”fragment”,”model”:”text”:” study. “,”attributes”:[]]}}]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Their second dose could be the same again, or a shot of Moderna or Novavax. “,”blocks”:[“type”:”fragment”,”model”:”text”:”Their second dose could be the same again, or a shot of Moderna or Novavax. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Chief investigator on the trial Prof Matthew Snape, from the Oxford Vaccine Group, said he hoped to recruit 1,050 volunteers who had already received one dose on the NHS in the past eight to 12 weeks. “,”blocks”:[“type”:”fragment”,”model”:”text”:”Chief investigator on the trial Prof Matthew Snape, from the Oxford Vaccine Group, said he hoped to recruit 1,050 volunteers who had already received one dose on the NHS in the past eight to 12 weeks. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”More than 800 people are already taking part in the research and have received two doses of either Pfizer, AstraZeneca or a mix. “,”blocks”:[“type”:”fragment”,”model”:”text”:”More than 800 people are already taking part in the research and have received two doses of either Pfizer, AstraZeneca or a mix. “,”attributes”:[]]]}},{“type”:”unorderedList”,”model”:{“blocks”:[{“type”:”listItem”,”model”:{“blocks”:[“type”:”urlLink”,”model”:”text”:”When will over 40s get the vaccine?”,”locator”:”https://www.bbc.co.uk/news/health-55045639″,”blocks”:[“type”:”fragment”,”model”:”text”:”When will over 40s get the vaccine?”,”attributes”:[]]]}},{“type”:”listItem”,”model”:{“blocks”:[“type”:”urlLink”,”model”:”text”:”How many people have been vaccinated so far?”,”locator”:”https://www.bbc.co.uk/news/health-55274833″,”blocks”:[“type”:”fragment”,”model”:”text”:”How many people have been vaccinated so far?”,”attributes”:[]]]}}]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Results of this first stage are expected next month and the expanded trial should have some reportable findings by June or July – although the study will run for a year. “,”blocks”:[“type”:”fragment”,”model”:”text”:”Results of this first stage are expected next month and the expanded trial should have some reportable findings by June or July – although the study will run for a year. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Health experts generally agree that the mixing and matching of the vaccines should be safe. The trial will check for any side-effects or unwanted reactions.”,”blocks”:[“type”:”fragment”,”model”:”text”:”Health experts generally agree that the mixing and matching of the vaccines should be safe. The trial will check for any side-effects or unwanted reactions.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Participants will have blood taken to check how well the vaccines trigger an immune response – in the form of antibodies and T cells – to combat Covid.”,”blocks”:[“type”:”fragment”,”model”:”text”:”Participants will have blood taken to check how well the vaccines trigger an immune response – in the form of antibodies and T cells – to combat Covid.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Meanwhile, a scientist advising the government has said a lot of experts are “very concerned” after a cluster of cases of the South African coronavirus variant were found in London.”,”blocks”:[“type”:”fragment”,”model”:”text”:”Meanwhile, a scientist advising the government has said a lot of experts are “very concerned” after a cluster of cases of the South African coronavirus variant were found in 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internationally”.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”He said the “starting point” was to see if a combination of vaccines were “as good in terms of their immune responses”, but that there were also “some hints” that a combination might give a better immune response overall.”,”blocks”:[“type”:”fragment”,”model”:”text”:”He said the “starting point” was to see if a combination of vaccines were “as good in terms of their immune responses”, but that there were also “some hints” that a combination might give a better immune response overall.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Earlier, Prof Snape said: “What I’m hoping is that we won’t rule out any combinations. That’s how we need to look at it: Are there any combinations we shouldn’t be giving, because they don’t generate a good immune response?””,”blocks”:[“type”:”fragment”,”model”:”text”:”Earlier, Prof Snape said: “What I’m hoping is that we won’t rule out any combinations. That’s how we need to look at it: Are there any combinations we shouldn’t be giving, because they don’t generate a good immune response?””,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”In other developments:”,”blocks”:[“type”:”fragment”,”model”:”text”:”In other developments:”,”attributes”:[]]]}},{“type”:”unorderedList”,”model”:{“blocks”:[{“type”:”listItem”,”model”:{“blocks”:[“type”:”urlLink”,”model”:”text”:”People aged 45 and over are being invited to make appointments for their Covid vaccinations”,”locator”:”https://www.bbc.co.uk/news/uk-56729897″,”blocks”:[“type”:”fragment”,”model”:”text”:”People aged 45 and over are being invited to make appointments for their Covid vaccinations”,”attributes”:[]],”type”:”fragment”,”model”:”text”:” in England, while Scotland is set to follow suit this week. In Northern Ireland and Wales, people aged over 40 are eligible”,”attributes”:[]]}},{“type”:”listItem”,”model”:{“blocks”:[“type”:”fragment”,”model”:”text”:”The US, South Africa and the European Union have “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”temporarily halted the rollout of the Johnson and Johnson single-dose vaccine”,”locator”:”https://www.bbc.co.uk/news/world-us-canada-56733715″,”blocks”:[“type”:”fragment”,”model”:”text”:”temporarily halted the rollout of the Johnson and Johnson single-dose vaccine”,”attributes”:[]],”type”:”fragment”,”model”:”text”:” after reports of rare cases of blood clotting – similar to those seen with the AstraZeneca jab”,”attributes”:[]]}},{“type”:”listItem”,”model”:{“blocks”:[“type”:”fragment”,”model”:”text”:”Scotland is preparing to “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”lift restrictions on travelling within the nation”,”locator”:”https://www.bbc.co.uk/news/uk-scotland-56733608″,”blocks”:[“type”:”fragment”,”model”:”text”:”lift restrictions on travelling within the nation”,”attributes”:[]],”type”:”fragment”,”model”:”text”:” from Friday, as well as allowing larger outdoor gatherings of up to six people from different households”,”attributes”:[]]}},{“type”:”listItem”,”model”:{“blocks”:[“type”:”fragment”,”model”:”text”:”The outbreak of the South Africa variant in south London is “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”thought to have begun with an individual who travelled from Africa in February”,”locator”:”https://www.bbc.co.uk/news/uk-england-london-56729607″,”blocks”:[“type”:”fragment”,”model”:”text”:”thought to have begun with an individual who travelled from Africa in February”,”attributes”:[]],”type”:”fragment”,”model”:”text”:”, official documents seen by the BBC suggest”,”attributes”:[]]}},”type”:”listItem”,”model”:”blocks”:[“type”:”fragment”,”model”:”text”:”Prof Sir David Spiegelhalter, a statistician from the University of Cambridge, told Today the prime minister was right to suggest lockdown 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my friend safely? “,”attributes”:[]]]}},{“type”:”listItem”,”model”:{“blocks”:[“type”:”fragment”,”model”:”text”:”LOOK-UP TOOL: “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”How many cases in your area?”,”locator”:”https://www.bbc.co.uk/news/uk-51768274″,”blocks”:[“type”:”fragment”,”model”:”text”:”How many cases in your area?”,”attributes”:[]]]}},{“type”:”listItem”,”model”:{“blocks”:[“type”:”fragment”,”model”:”text”:”LOCKDOWN RULES: “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”What are they and when will they end?”,”locator”:”https://www.bbc.co.uk/news/explainers-52530518″,”blocks”:[“type”:”fragment”,”model”:”text”:”What are they and when will they end?”,”attributes”:[]]]}}]}},{“type”:”image”,”model”:{“media”:”__typename”:”ComponentsImage”,”originalSrc”:”https://c.files.bbci.co.uk/D7D8/production/_111165255_cps_web_banner_bottom_640x3-nc.png”,”iChefRecipe”:”https://ichef.bbci.co.uk/news/$recipe/cpsprodpb/D7D8/production/_111165255_cps_web_banner_bottom_640x3-nc.png”,”height”:33,”width”:1920,”alt”:”Banner”,”loading”:”lazy”,”blocks”:[{“type”:”altText”,”model”:{“blocks”:[“type”:”text”,”model”:”blocks”:[“type”:”fragment”,”model”:”text”:”Banner”,”attributes”:[]]]}},”type”:”rawImage”,”model”:”height”:33,”width”:1920,”locator”:””,”originCode”:””,”copyrightHolder”:”BBC”,”originalSrc”:”https://c.files.bbci.co.uk/D7D8/production/_111165255_cps_web_banner_bottom_640x3-nc.png”,”iChefRecipe”:”https://ichef.bbci.co.uk/news/$recipe/cpsprodpb/D7D8/production/_111165255_cps_web_banner_bottom_640x3-nc.png”]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”So far more than 32 million people in the UK have received the first dose of a coronavirus vaccine, while 7.8 million people had both doses.”,”blocks”:[“type”:”fragment”,”model”:”text”:”So far more than 32 million people in the UK have received the first dose of a coronavirus vaccine, while 7.8 million people had both doses.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Outside of the trial, people should still receive the same type of Covid-19 vaccine for their first and second doses, although they can be given different brands if the same vaccine is not available.”,”blocks”:[“type”:”fragment”,”model”:”text”:”Outside of the trial, people should still receive the same type of Covid-19 vaccine for their first and second doses, although they can be given different brands if the same vaccine is not available.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”The Moderna vaccine is already approved for use in the UK and works in a similar way to the Pfizer/BioNTech one, using a small amount of genetic code from coronavirus to teach the body how to fight off infection. “,”blocks”:[“type”:”fragment”,”model”:”text”:”The Moderna vaccine is already approved for use in the UK and works in a similar way to the Pfizer/BioNTech one, using a small amount of genetic code from coronavirus to teach the body how to fight off infection. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”The Oxford-AstraZeneca vaccine is slightly different and uses a harmless, modified virus to carry instructions on how to beat Covid. “,”blocks”:[“type”:”fragment”,”model”:”text”:”The Oxford-AstraZeneca vaccine is slightly different and uses a harmless, modified virus to carry instructions on how to beat Covid. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[{“type”:”paragraph”,”model”:{“text”:”The Novavax jab has not been approved yet in the UK, but is expected to be soon, since trials show it is safe and effective. “,”blocks”:[“type”:”fragment”,”model”:”text”:”The Novavax jab has not been approved yet in the UK, but is expected to be soon, since trials show it is “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”safe and effective”,”locator”:”https://www.bbc.co.uk/news/uk-55850352″,”blocks”:[“type”:”fragment”,”model”:”text”:”safe and effective”,”attributes”:[]],”type”:”fragment”,”model”:”text”:”. “,”attributes”:[]]}}]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”It uses proteins from coronavirus that can train the immune system without causing infection. “,”blocks”:[“type”:”fragment”,”model”:”text”:”It uses proteins from coronavirus that can train the immune system without causing infection. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”The UK is not the only country considering using mixed dosing. “,”blocks”:[“type”:”fragment”,”model”:”text”:”The UK is not the only country considering using mixed dosing. “,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[{“type”:”paragraph”,”model”:{“text”:”Head of China’s Center for Disease Control and Prevention, George Gao, recently said China should consider it to boost vaccine effectiveness.”,”blocks”:[“type”:”fragment”,”model”:”text”:”Head of China’s Center for Disease Control and Prevention, George Gao, recently said “,”attributes”:[],”type”:”urlLink”,”model”:”text”:”China should consider it to boost vaccine effectiveness”,”locator”:”https://www.bbc.co.uk/news/world-asia-china-56713663″,”blocks”:[“type”:”fragment”,”model”:”text”:”China should consider it to boost vaccine effectiveness”,”attributes”:[]],”type”:”fragment”,”model”:”text”:”.”,”attributes”:[]]}}]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Russia’s Sputnik V vaccine involves using two slightly different doses to give immunity.”,”blocks”:[“type”:”fragment”,”model”:”text”:”Russia’s Sputnik V vaccine involves using two slightly different doses to give immunity.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”Prof Jeremy Brown, a member of the UK’s Joint Committee of Vaccination and Immunisation, which advises on vaccines, said in coming years people will eventually “have to” have a mix of Covid-19 jabs.”,”blocks”:[“type”:”fragment”,”model”:”text”:”Prof Jeremy Brown, a member of the UK’s Joint Committee of Vaccination and Immunisation, which advises on vaccines, said in coming years people will eventually “have to” have a mix of Covid-19 jabs.”,”attributes”:[]]]}},{“type”:”text”,”model”:{“blocks”:[“type”:”paragraph”,”model”:”text”:”He told the BBC: “It’s practically going to have to be that way because, once you’ve completed a course of, say, the Moderna or Pfizer or the AstraZeneca, with two doses – in the future, it’s going to be quite difficult to guarantee you get the same type of vaccine again.””,”blocks”:[“type”:”fragment”,”model”:”text”:”He told the BBC: “It’s practically going to have 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